Endocrine Abstracts

Gaucher disease (GD) is autosomal recessive lysosomal storage disorder caused by the deficiency of glucocerebrosidase with consequent massive acumulation of lipid-laden macrophages in various tissues. Estimated life expectancy is about 9 years shorter than for the reference population. Mortality due to macrovascular diseases is higher, and probably associated with metabolic abnormalities found in GD type 1 patients, including decreases in serum adiponectin levels. Because adip...

The aim of this study was to compare metabolic profile in hypertensive obese and lean subjects. The study population consisted of 76 patients. We measured fasting glucose and insulin levels, triglycerides, total, LDL and HDL cholesterol. We also estimated the BMI, WHR, systolic (SBP) and diastolic blood pressure (DBP). We used WHO criteria for abdominal obesity (WHR>0.90 men, >0.85 women), and WHO criteria for diagnosing the metabolic syndrome (triglyceride>1.7 mmo...

Introduction: Multiple endocrine neoplasia type 1 syndrome (MEN1sy.) is a complex disease predisposing to a variety of multifocal neuroendocrine tumors (NET). Approximately 5% of pancreatic VIPomas and glucagonomas are associated with MEN1sy., most of them with metastases at diagnosis.Case report: A 15-year-old boy was admitted with primary hyperparathyroidism, pituitary microadenoma (6 mm) and suspected MEN1sy. His father had primary hyperparathyroidism...